Set in the weeks after Resistance: Fall of Man, Resistance: Retribution follows the story of former British Marine James Grayson. After a personal tragedy - he is forced to kill his own brother inside a Chimeran conversion centre - Grayson goes on a vendetta to destroy every conversion centre he can find, but eventually learns that his efforts have been futile. The European resistance - the Maquis - enlist Grayson's help to retake Europe in Operation Overstrike.